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目的 观察吸入类固醇二丙酸倍氯米松 (BDP)干粉剂对晚发老年哮喘 (LOA)的疗效。 方法 将 2 2例LOA患者与 2 3例非老年哮喘患者进行对比研究 ,观察吸入 β2 受体激动剂沙丁胺醇干粉剂后 1秒钟用力呼气容积 (FEV1)的变化以及吸入BDP干粉剂后FEV1及其占预计值百分比(FEV1% )、早晚最大呼气流速 (PEFR)及其日内变异率等变化。 结果 两组患者在吸入沙丁胺醇干粉剂后FEV1均明显增高 (P <0 0 1) ,但非老年组FEV1升高较LOA更明显 (P <0 0 1)。在BDP干粉剂吸入 1周和 4周时 ,两组FEV1、FEV1%和PEFR均明显增高 (P <0 0 1) ,PEFR日内变异率明显下降 (P<0 0 1)。于治疗 1周时两组间FEV1%差异无显著性。 结论 BDP干粉剂能有效控制LOA。
Objective To observe the efficacy of inhaled steroid dipropionate dipropionate (BDP) dry powder on senile asthma (LOA). Methods Twenty-two cases of LOA were compared with 23 non-elderly asthmatic patients. The change of forced expiratory volume (FEV1) one second after inhaling beta2-agonist salbutamol dry powder and FEV1 and Its percentage of expected value (FEV1%), morning and evening maximum expiratory flow rate (PEFR) and intra-day variability and other changes. Results Both groups had significantly higher FEV1 after inhaling salbutamol (P <0.01), but the FEV1 in non-elderly group was higher than that of LOA (P <0.01). The FEV1, FEV1% and PEFR were significantly increased in both groups (P <0.01) at 1 week and 4 weeks of inhalation of BDP, and the intraday variation rate of PEFR was significantly decreased (P <0.01). There was no significant difference in FEV1% between the two groups at 1 week of treatment. Conclusion BDP dry powder can effectively control LOA.