HLA(Human Leukocyte Antigen)即人类白细胞抗原,与免疫反应的遗传调控有关,是最复杂的人类遗传多态性系统。HLA区的基因群有ABC和D/DR四个位点,近年来发现某些肿瘤细胞膜上HLA表达异常,表现为量和分布上的得失、增减,它对肿瘤与宿主的免疫监视和免疫排斥有重要的生物学意义。本文以外科手术非淋巴组织及其恶性肿瘤标本,用三种单克隆抗体(McAb)作 HLA (Human Leukocyte Antigen), human leukocyte antigen, is related to the genetic regulation of immune response and is the most complex human genetic polymorphism system. In HLA region, the gene cluster has four sites of ABC and D / DR. In recent years, it has been found that some tumor cells have abnormal HLA expression on the membrane, which shows the quantity and distribution of gains and losses, increase and decrease, it is immune surveillance and immune to tumor and host Exclusion has important biological significance. In this paper, surgical non-lymphoid tissue and its malignant tumor specimens, with three monoclonal antibodies (McAb) for