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目的 :研究肝源性糖代谢紊乱与 2型糖尿病红细胞胰岛素受体的变化。方法 :采用受体放射分析法检测2 4例肝病患者、3 0例糖尿病患者和 2 4例健康者的红细胞胰岛素受体及胰岛素、C肽水平。结果 :肝病组高亲和力型胰岛素受体数目 (R1)降低 ,餐后胰岛素水平增高 ,糖尿病组高、低亲和力型胰岛素受体数目 (R1、R2 )及低亲和常数K2均降低。结论 :肝源性糖代谢紊乱与 2型糖尿病均存在红细胞胰岛素受体的异常 ,但两者之间无显著性差异。
Objective: To study the changes of hepatic glucose metabolism disorder and insulin receptor in type 2 diabetic erythrocytes. Methods: Erythrocyte insulin receptor, insulin and C-peptide levels in 24 patients with liver disease, 30 diabetes patients and 24 healthy controls were detected by radioimmunoassay. Results: The number of high-affinity insulin receptor (R1) and postprandial insulin in liver disease group were increased. The number of high and low affinity insulin receptor (R1, R2) and low affinity constants K2 in diabetic group decreased. Conclusion: There are abnormalities of erythrocyte insulin receptor in both hepatic glucose metabolism disorder and type 2 diabetes mellitus, but there is no significant difference between them.