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目的:不同胰岛素使用方法治疗2型糖尿病的血糖达标及安全性比较。方法:收集2016年1月~2016年12月在我院内分泌科初次诊断的2型糖尿病患者158名。根据患者自愿的原则,随机分为三组,甲组52名,乙组54名,丙组52名。甲组给予:门冬胰岛素三餐前皮下注射、乙组给予短效人胰岛素三餐前皮下注射+甘精胰岛素组睡前皮下注射,乙组给予短效人胰岛素,胰岛素泵持续皮下注射。观察三组患者治疗前后血糖控制情况及低血糖发生人次。结果:三组患者治疗后血糖下降均有显著,低血糖发生率无差异,而降糖效果最好的为丙组,即使用胰岛素泵持续皮下注射患者,然后是甘精胰岛素的患者,最后是甲组。结论:胰岛素泵持续皮下注射降糖效果较理想,但因胰岛素泵较贵,建议使用甘精胰岛素。
Objective: To compare the blood sugar compliance and safety of different insulin therapy in type 2 diabetes mellitus. Methods: A total of 158 Type 2 diabetic patients diagnosed in Department of Endocrinology from January 2016 to December 2016 were collected. According to the principle of voluntary patients were randomly divided into three groups, Group A 52, Group B 54, Group C 52. Group A given: aspart insulin subcutaneous injection before meals, Group B short-acting human insulin three meals before subcutaneous injection + insulin glargine group before bedtime subcutaneous injection, short-acting human insulin given to group B, insulin pump sustained subcutaneous injection. Three groups of patients before and after treatment to observe the control of blood glucose and hypoglycemia occurred. Results: After treatment, the three groups of patients had significant decrease in blood sugar, no difference in the incidence of hypoglycemia, while the best hypoglycemic effect was in group C, ie patients were continuously injected subcutaneously with insulin pump followed by insulin glargine and finally Group A CONCLUSION: Continuous hypodermic infusion of insulin pump is more effective than hypoglycemic insulin, but insulin pump is more expensive because insulin pump is recommended.