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目的研究OGTT 1h高血糖人群的β细胞功能。方法将1 177例受试者分为正常糖耐量(NGT)、糖调节受损(IGR)和糖尿病(DM)三组。前两组再依据OGTT 1hPG水平分为NGTN、NGT1H和IGRN、IGR1H四个亚组。将IGR组再分为空腹血糖受损(IFG)组和糖耐量受损(IGT)组以及IFG+IGT组。HOMA-IR评估胰岛素敏感性,HOMA-β、AI_(30)/△G_(30)(IGI)、葡萄糖OGTT曲线下面积(AUCg)评估胰岛β细胞分泌功能。结果 (1)NGTN和IGRN组分别比NGT1H和IGR1H组的IGI高(P<0.05);HOMA-IR、AUCg在两亚组间均无统计学差异。(2)NGT1H组比IFG组和IGT组具有较高的AUCg,其HOMA-β比IFG组高,三组间HOMA-IR和IGI差异无统计学意义。结论 NGT1H人群已存在胰岛β细胞功能异常,可能为胰岛素分泌缺陷尤其是早期相分泌受损所致。
Aim To study the β-cell function in OGTT 1h hyperglycemia. Methods 1 177 subjects were divided into three groups: normal glucose tolerance (NGT), impaired glucose regulation (IGR) and diabetes mellitus (DM). According to OGTT 1hPG level, the first two groups were divided into four subgroups: NGTN, NGT1H, IGRN and IGR1H. The IGR group was further divided into fasting glucose (IFG) group and impaired glucose tolerance (IGT) group and IFG + IGT group. HOMA-IR was used to evaluate the insulin secretion, HOMA-β, AI_ (30) / △ G_ (30) (IGI) and area under the curve of glucose OGTT (AUCg) Results (1) IGT was higher in NGTN and IGRN groups than in NGT1H and IGR1H groups (P <0.05). There was no significant difference in HOMA-IR and AUCg between the two subgroups. (2) NGT1H group had higher AUCg than IFG group and IGT group, and HOMA-β was higher than IFG group. There was no significant difference between the three groups in HOMA-IR and IGI. Conclusion NGT1H patients have dysfunction of pancreatic β-cells, which may be caused by impaired insulin secretion, especially early phase secretion.