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目的：研究十二指肠球部溃疡和慢性浅表性胃炎患者胃液的ＮＯ水平，以及胃液ＮＯ水平与幽门螺杆菌（ＨＰ）感染的可能联系。方法：通过胃镜，抽取２３例十二指肠球部溃疡患者、２１例慢性浅表性胃炎患者和１９例正常人的胃液。用Ｇｒｉｅｓ法测胃液中ＮＯ水平。结果：十二指肠球部溃疡患者胃液ＮＯ水平是（３５．５６±６．１５μｍｏｌ／Ｌ），ＨＰ感染者是（３４．１２±８．１０μｍｏｌ／Ｌ）。两者显著高于正常个体（１８．６０±３．０７μｍｏｌ／Ｌ）。慢性浅表性胃炎患者（１９．７３±２．３２μｍｏｌ／Ｌ）和ＨＰ阴性者（２０．２６±３．４４μｏｍｌ／Ｌ）胃液中ＮＯ水平（Ｐ＜０．０１）。结论：结果提示ＮＯ可能是引起十二指肠球部溃疡的一个因素，ＨＰ感染可能是十二指肠球部溃疡患者胃液中ＮＯ增高的原因
Objective: To study the level of NO in gastric juice of patients with duodenal ulcer and chronic superficial gastritis and the possible relationship between NO level in gastric juice and Helicobacter pylori (HP) infection. Methods: Gastroscopy was performed in 23 patients with duodenal ulcer, 21 patients with chronic superficial gastritis and 19 normal persons. Gries method to measure the level of NO in gastric juice. Results: The level of NO in gastric juice of duodenal ulcer patients was (35.56 ± 6.15μmol / L) and that of HP patients (34.12 ± 8.10μmol / L). Both were significantly higher than normal individuals (18.60 ± 3.07μmol / L). The levels of NO in gastric mucosa of patients with chronic superficial gastritis (19.73 ± 2.32μmol / L) and those with HP negative (20.26 ± 3.44μoml / L) (P <0.01). CONCLUSIONS: The results suggest that NO may be a contributing factor to duodenal ulcer. HP infection may be responsible for the increased NO in gastric juice in patients with duodenal ulcer