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芬托拉明(Phentolamine)以0.3毫克/分的速率给充血性心力衰竭病人输注时,可产生显著的血液动力学改善,增加心肌收缩力。另一方面也发现此药能引起血管平滑肌的直接松弛。因而作者给冠状动脉疾病和心绞痛病人试用芬托拉明,本文报告试用的效果。方法:12例病人在给安慰剂或芬托拉明之前和给药后第7天,使作运动试验直到发生心绞痛为止。病人平均58岁(38～71岁),每例在受试前均有稳定性心绞痛至少6个月,7例并具有陈旧性心肌梗死的心
Infusion of Phentolamine at a rate of 0.3 mg / min for patients with congestive heart failure produces significant hemodynamic improvements and increases myocardial contractility. On the other hand also found that the drug can cause direct relaxation of vascular smooth muscle. The authors therefore tried captopril for patients with coronary artery disease and angina, and this article reports on trial results. METHODS: Twelve patients were given exercise tests until angina pectoris before placebo or titramin and at day 7 after dosing. Patients, mean 58 years (range, 38-71 years), had stable angina for at least 6 months prior to the study and 7 had a heart with old myocardial infarction