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通过较简单的合成路线,制备了一种吸附性能良好的低密度脂蛋白吸附剂. 首先采用相转移法制备了多孔壳聚糖珠,再以乙二醇二缩水甘油醚对其同时进行活化、交联并引入一定长度的手臂,进而偶联色氨酸作为配基.试验表明,该吸附剂对低密度脂蛋白具有较高的吸附容量和较好的吸附选择性,并具有很好的血液相容性.实验考察了长短不同的手臂对吸附剂吸附选择性的影响,并对其作用机制进行了探讨.
A simple adsorbent with low adsorption capacity was prepared by a relatively simple synthetic route.Porous chitosan beads were prepared by phase transfer method and then activated by ethylene glycol diglycidyl ether Cross-linked and the introduction of a certain length of the arm, and then conjugated tryptophan as ligand.Experiments showed that the adsorbent for low density lipoprotein has a high adsorption capacity and good adsorption selectivity, and has good blood Compatibility The experiment investigated the effect of different length of arms on the adsorption selectivity of adsorbents, and explored its mechanism of action.