葡萄柚及其果汁在中国的消费量在日益增长,因其富含果胶、黄酮类、呋喃香豆素及其他许多化学成分,日益为消费者所喜爱。葡萄柚汁通过对肠道转运蛋白及肠黏膜上皮细胞上代谢酶的影响从而改变很多口服药物的生物利用度。本文就国外近几年关于葡萄柚汁与药物相互作用的文献报道简要综述,并提出建议和展望。 The growing consumption of grapefruit and its fruit juices in China is increasingly appealing to consumers because of its high content of pectin, flavonoids, furanocoumarins and many other chemical ingredients. Grapefruit juice alters the bioavailability of many oral drugs by affecting the intestinal transport proteins and metabolic enzymes in the intestinal epithelial cells. This paper summarizes the literature review about the interaction between grapefruit juice and drugs in foreign countries in recent years, and puts forward suggestions and prospects.