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探讨血浆可溶性P-选择素(sP-selectin)在原发性肝癌患者中的临床意义。应用ELISA法检测139例原发性肝癌患者血浆sP-selectin的水平。原发性肝癌患者血浆sP-selectin含量明显高于正常对照组(P<0.01),其中临床Ⅱ期患者高于临床Ⅰ期患者,而临床Ⅲ期患者又高于临床Ⅱ期患者。术后第15d,患者血浆sP-selectin含量较术前明显降低(P<0.01),但仍明显高于正常对照组(P<0.01)。术后第30d,患者血浆sP-selectin含量较术后第15d进一步降低(P<0.01),与正常对照组比较差异无显著性(P>0.05)。提示原发性肝癌患者血浆sP-selectin水平明显高于正常人,而且其水平与病情呈正相关。手术切除肝癌可降低患者血浆sP-selectin水平。血浆sP-selectin的检测及动态观察可能对原发性肝癌的辅助诊断、病情发展的判断、疗效观察以及预后估计具有一定的临床意义。
To investigate the clinical significance of plasma soluble P-selectin in patients with primary liver cancer. The plasma levels of sP-selectin in 139 patients with primary liver cancer were detected by ELISA. The plasma levels of sP-selectin in patients with primary liver cancer were significantly higher than those in the normal control group (P <0.01). The clinical stage Ⅱ patients were higher than the clinical stage Ⅰ patients, while those in stage Ⅲ were higher than those in stage Ⅱ patients. On the 15th postoperative day, the plasma sP-selectin level in patients was significantly lower than that before the operation (P <0.01), but still significantly higher than that in the normal control group (P <0.01). The level of plasma sP-selectin in the patients at the 30th day after operation was significantly lower than that at the 15th day after operation (P <0.01). There was no significant difference between the two groups (P> 0.05). Tip of patients with primary liver cancer plasma sP-selectin levels were significantly higher than normal, and its level was positively correlated with the disease. Surgical resection of liver cancer can reduce plasma sP-selectin levels in patients. The detection and dynamic observation of plasma sP-selectin may have some clinical significance for the auxiliary diagnosis of primary liver cancer, the judgment of the disease progression, the observation of the curative effect and the prognosis.