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静脉注射肾上腺素可造成大鼠致死性肺水肿,这种水肿类似临床上的中枢性肺水肿,属于混合性肺水肿。既有肺毛细血管压力升高,又有肺毛细血管通透性增高。用中药山莨菪碱进行预防效果十分明显。电镜观察提供了这种预防效果的超微结构基础。水肿组内皮细胞及肺泡上皮细胞膨隆,水肿,部份细胞从基底膜脱落,基底膜裸露或断裂。间质腔及肺泡腔充满富含蛋白的水肿液。而预治组病变明显减轻,水肿液明显减少。内皮细胞及上皮细胞基本正常。间质、肺膈增宽,结缔组织增生。这是由于动物存活半个月,炎症被吸收有关。实验表明,山莨菪碱可以明显抑制血管通透性的增高。
Intravenous epinephrine can cause fatal pulmonary edema in rats, this edema is similar to clinical central pulmonary edema, is a mixed pulmonary edema. Both pulmonary capillary pressure, and pulmonary capillary permeability increased. Chinese medicine Anisodamine prevention effect is very obvious. Electron microscopy provides the basis for this ultrastructural prophylaxis. Edema group of endothelial cells and alveolar epithelial cells bulging, edema, some cells fall off from the basement membrane, the basement membrane bare or broken. Interstitial cavity and alveolar cavity filled with protein-rich edema. The pretreatment group lesions significantly reduced edema significantly reduced. Endothelial cells and epithelial cells were normal. Interstitial, lung diaphragm widened, connective tissue hyperplasia. This is due to animal survival for half a month, the inflammation is absorbed. Experiments show that anisodamine can significantly inhibit the increase of vascular permeability.