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目的分析大规模人群应用甲型H1N1流行性感冒疫苗后的预防接种不良反应特征,进一步观察该疫苗的安全性。方法通过国家疑似预防接种异常反应监测系统,收集广州市2009年10月28日~2010年8月31日期间的甲型H1N1流感疫苗接种信息和接种后疑似预防接种不良反应个案数据,分析相关特征。结果共接种575 412人,报告183例预防接种不良反应,不良反应发生率为31.80/10万,其中异常反应发生率为5.39/10万;52.5%的不良反应发生在接种疫苗后24 h内,以发热、红肿多见,多数不良反应预后良好。接种疫苗后出现急性播散性脑脊髓炎2例,为13岁及15岁男孩各1名,其中1例死亡。结论大规模接种甲型H1N1流感疫苗后预防接种不良反应的发生率低,但需警惕严重不良反应的发生。
Objective To analyze the characteristics of adverse reactions of vaccination against influenza A (H1N1) in large-scale population and further observe the safety of the vaccine. Methods Through the National Monitoring System for Suspected Vaccination Abnormal Response, we collected information on influenza A (H1N1) vaccination and the data of suspected vaccination adverse reactions after vaccination in Guangzhou from October 28, 2009 to August 31, 2010, and analyzed the related characteristics . Results A total of 575 412 persons were inoculated and 183 adverse reactions were reported. The incidence rate of adverse reactions was 31.80 / 100 000, of which 5.39 / 100 000. The adverse reactions occurred in 52.5% within 24 h after vaccination, To fever, more common red, most adverse reactions with good prognosis. Two cases of acute disseminated encephalomyelitis occurred after vaccination, one for each of 13-year and 15-year-old boys, of whom 1 died. Conclusion The incidence of adverse reactions after immunization with large-scale influenza A (H1N1) vaccination is low, but serious adverse reactions need to be observed.