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目的探讨可溶性细胞间粘附分子１（ｓＩＣＡＭ１）和可溶性内皮细胞白细胞粘附分子１（ｓＥＬＡＭ１）含量与胃肠道肿瘤患者预后的关系。方法用双抗体夹心法测定６４例临床患者血清中ｓＩＣＡＭ１和ｓＥＬＡＭ１的含量。结果胃肠道良性病变患者血中ｓＩＣＡＭ１和ｓＥＬＡＭ１的含量均不升高（Ｐ＞０．０５）；而它们在胃肠道癌患者中的含量明显升高（Ｐ＜０．０１）；伴有肝转移的胃肠道肿瘤患者血中ｓＩＣＡＭ１的含量比无肝转移的癌患者有非常显著的升高（Ｐ＜０．０１），而ｓＥＬＡＭ１的含量相差无显著性（Ｐ＞０．０５）。结论ｓＩＣＡＭ１的含量与胃肠道癌预后有关。
Objective To investigate the relationship between soluble intercellular adhesion molecule-1 (sICAM-1) and soluble endothelial cell leukocyte adhesion molecule-1 (sELAM-1) levels and the prognosis of patients with gastrointestinal cancer. Methods The levels of sICAM-1 and sELAM-1 in serum of 64 clinical patients were determined by double antibody sandwich method. Results The levels of sICAM-1 and sELAM-1 in patients with gastrointestinal benign lesions did not increase (P>0.05), but their levels in patients with gastrointestinal cancer increased significantly (P<0.01). The content of sICAM-1 in patients with gastrointestinal cancer with hepatic metastasis was significantly higher than that in patients without liver metastasis (P<0.01), but there was no significant difference in the content of sELAM-1. (P>0.05). Conclusion The content of sICAM-1 is related to the prognosis of gastrointestinal cancer.