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AIM To determine levels of cytokines incolonic mucosa of asymptomatic first degreerelatives of Crohn’s disease patients.METHODS Cytokines(Interleukin(IL)1-Beta,IL-2,IL-5 and IL-8)were measured using ELISAin biopsy samples of normal looking colonicmucosa of first degree relatives of Crohn’sdisease patients(n = 9)and from normalcontrols(n = 10)with no family history ofCrohn’s disease.RESULTS Asymptomatic first degree relativesof patients with Crohn’s disease had significantlyhigher levels of basal intestinal mucosalcytokines(IL-2,IL-5 and IL-8)than normalcontrols.Whether these increased cytokinelevels serve as phenotypic markers for a geneticpredisposition to developing Crohns diseaselater on,or whether they indicate early(pre-clinical)damage has yet to be further defined.CONCLUSION Asymptomatic first degreerelatives of Crohn’s disease patients have higherlevels of cytokines in their normal-lookingintestinal mucosa compared to normal controls,This supports the hypothesis that increasedcytokines may be a cause or an early event inthe inflammatory cascade of Crohns disease andare not merely a result of the inflammatoryprocess.
AIM To determine levels of cytokines incolonic mucosa of asymptomatic first degree relatives of Crohn’s disease patients. METHODS Cytokines (Interleukin (IL) 1-Beta, IL-2, IL-5 and IL-8) were measured using ELISA in biopsy samples of normal looking colonic mucosa of first degree relatives of Crohn’s disease patients (n = 9) and from normal controls (n = 10) with no family history of Crohn’s disease. RESULTS Asymptomatic first degree relatives of patients with Crohn’s disease had significantlyhigher levels of basal intestinal mucosalcytokines (IL- IL-5 and IL-8) than normal controls. Whehe these increased cytokinelevels serve as phenotypic markers for a genetic predisposition to developing Crohns disease later on, or whether they indicate early (pre-clinical) damage has yet to be further defined .CONCLUSION Asymptomatic first degreerelatives of Crohn’s disease patients have higherlevels of cytokines in their normal-lookingintestinal mucosa compared to normal controls, This supports the hypothesis that increasedcy tokines may be a cause or an early event inthe inflammatory cascade of Crohns disease and not only a result of the inflammatory process.