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目的 探讨以生物蛋白胶为载体配合丝裂霉素缓释化疗辅助治疗腹腔恶性肿瘤的有效性和安全性。方法 将 5 3例腹腔恶性肿瘤患者随机分为实验组 (n =2 7) ,对照组 (n =2 6) ,术后实验组将生物蛋白胶溶解丝裂霉素喷洒在腹腔及瘤床周围 ,对照组未使用 ,比较实验组与对照组的疗效差异。结果 术后实验组和对照组患者化疗不良反应的发生率分别为 5 4.2 % ,61.5 % ,两组无显著差异 (P >0 .0 5 )。术后 1年 ,对照组生存率为 5 0 % ,实验组生存率为 77.8% ,两组有统计学差异 (P <0 .0 5 )。结论 以生物蛋白胶为载体配合丝裂霉素术后腹腔缓释化疗能够延长病人的生存期 ,安全有效。
Objective To investigate the efficacy and safety of bioprotein gel as a carrier combined with mitomycin-releasing sustained-release chemotherapy in the treatment of malignant tumors of the abdominal cavity. Methods Fifty-three patients with malignant tumors of the abdominal cavity were randomly divided into experimental group (n = 27) and control group (n = 26). Postoperative experimental group was treated with bioprotein gel dissolved mitomycin spray around the abdominal cavity and tumor bed , The control group did not use, comparing the experimental group and the control group differences in efficacy. Results The incidence of adverse reactions of chemotherapy in experimental group and control group were respectively 5.22% and 61.5%, there was no significant difference between the two groups (P> 0.05). One year after operation, the survival rate of the control group was 50%, and the survival rate of the experimental group was 77.8%. There was a significant difference between the two groups (P <0.05). Conclusion The combination of bioprotein gel and mitomycin C for postoperative intraperitoneal sustained-release chemotherapy can prolong the survival of patients and is safe and effective.