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目的:通过小柴胡汤促进四物汤改善血虚小鼠造血机能的实验研究,探讨“少阳春生之气”对气血化生的有促进作用。方法:制造小鼠血虚模型后分别采用早晚两个时段,以四物汤与小柴胡汤合煎剂、四物汤、四物汤小剂量和小柴胡汤小剂量灌胃给药,测定给药各组对小鼠WBC、RBC、HGB、HCT、PLT各项血常规指标以及促红细胞生成素(EPO)的含量的影响。结果:早上给药后小柴胡汤小剂量组对RBC、HGB、HCT的含量显示出了作用,P<0.05;晚上给药后四物汤组对HGB的含量显示出了作用,P<0.05;小柴胡汤小剂量组对HCT的含量显示出了作用,P<0.05。结论:小柴胡汤有促进四物汤补血功效发挥的作用,说明李东垣“少阳春生之气”理论对治疗血虚有临床指导意义。
OBJECTIVE: To promote the experimental study of hematopoietic function of Siwu Decoction in mice with deficiency of blood through Xiao Chai Hu Tang, and to explore the effect of Siyang Decoction on promoting Qi and blood metaplasia. Methods: After the mice model of blood deficiency was made, the rats were treated with small dose of Siwu Decoction, Xiaochaihu decoction, Siwu Decoction, Siwu Tang small dose and Xiao Chai Hu Tang respectively. Group on the mouse WBC, RBC, HGB, HCT, PLT various blood parameters and erythropoietin (EPO) content. Results: The small dose of Xiaochaihu decoction after morning administration showed a significant effect on the contents of RBC, HGB and HCT, P <0.05. After the evening administration, Siguo decoction showed the effect on the content of HGB, P <0.05; Xiao Chai Hu Tang low-dose group on the HCT content showed an effect, P <0.05. Conclusion: Xiao Chai Hu Tang has the effect of promoting blood circulation effect of Si Wu Tang. It shows that Li Dong Yuan ’s theory of “Shao Yang Chu Sheng Qi” has clinical significance in treating blood deficiency.