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目的：观察醒脑清眩胶囊的降压作用及其对眩晕的影响。方法：①测正常麻醉猫１次ｉｄ和清醒ＳＨＲ多次ｉｇ给药的降压作用；②以氯仿引起的眼球震颤的潜伏期和持续时间评定药对眩晕的影响；③测定药物对正常和痉挛状态下的脑基底动脉的作用。结果：①１次ｉｄ醒脑清眩胶囊２．８ｇ·ｋｇ－１明显降低猫血压；每天１次，连续１４ｄｉｇ生药１．４，２．８，５．６ｇ·ｋｇ－１使ＳＨＲ的血压明显下降；②１次ｉｇ２．８，５．６ｇ·ｋｇ－１，连续３次，使氯仿引起的眼球震颤的潜伏期延长１４．４％和１３．０％，眼球震颤的持续时间缩短３３．３％和２３．３％；③醒脑清眩胶囊明显舒张由ＫＣｌ和５ＨＴ引起的狗脑基底动脉痉挛，测得其ＩＣ５０分别为０．３３８（０．１～３．０ｍｇ·ｍｌ－１的抑制率在１８．０％～９７．３％）和０．４７５ｍｇ·ｍｌ－１（０．１～３．２ｍｇ·ｍｌ－１的抑制率在１２．９％～９３％）。结论：醒脑清眩胶囊有明显的降压和抗眩晕作用，这些作用与扩张脑血管，包括扩张基底动脉有关。
Objective: To observe the antihypertensive effect of Xingnaoqingxuan capsule and its effect on vertigo. Methods: 1 To measure the antihypertensive effect of multiple ig administrations of id and conscious SHR in normal anesthetized cats; 2 To assess the influence of drugs on vertigo with the incubation period and duration of nystagmus caused by chloroform; 3 To determine the drug’s effect on normal and spasticity The role of the basilar artery underneath. Results: 11 times id Xingnao Qingxuan capsules 2.8g kg-1 significantly reduced cat blood pressure; once a day, continuous 14dig crude drug 1.4, 2.8, 5.6g kg-1 make SHR blood pressure decreased significantly ; 21 ig2.8, 5.6g·kg-1, 3 times in a row, the incubation period of nystagmus caused by chloroform was prolonged by 14.4% and 13.0%, the duration of nystagmus shortened by 33.3% and 23; .3%; 3 Xingnao Qingxuan Capsules markedly relaxes the basilar artery spasm induced by KCl and 5-HT in dogs, and its IC50 is 0.338 (inhibition rate of 0.1 to 3.0 mg·ml-1). In the range of 18.0% to 97.3%) and 0.475 mg·ml-1 (inhibition rate of 0.1 to 3.2 mg·ml-1 was 12.9% to 93%). Conclusion: Xingnao Qingxuan Capsule has obvious antihypertensive and anti-vertigo effects. These effects are related to the expansion of cerebral blood vessels, including the expansion of the basilar artery.