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目的探讨血清铜、锌含量与前列腺癌之间的关系,并将其与血清前列腺特异性抗原(PSA)比较,探讨其在前列腺癌诊断中价值比较。方法采用原子吸收分光光度法测定76例前列腺癌患者、125例前列腺增生患者和191例健康男性的血清铜、锌含量。结果前列腺癌组血清锌明显低于健康对照组,血清铜和铜/锌比值明显高于健康对照组(P<0.05)。前列腺癌组血清铜及铜/锌比值与前列腺增生组比较未见显著性差异;前列腺癌组血清锌低于前列腺增生组(P<0.05)。前列腺增生组血清锌与健康对照组比较未见显著性差异;前列腺增生组血清铜和铜/锌比值高于健康对照组(P<0.05)。PSA在4.0-10.0ng/ml灰色区域的前列腺癌组,血清锌ROC-AUC(receiver operator characteristic curve-area under curve)为66%,高于PSA的ROC-AUC。结论血清铜、铜/锌比值升高及血清锌降低可能是前列腺癌发生的危险因素,血清锌在PSA(4.0～10.0)ng/ml灰色区域的前列腺癌诊断效率高于PSA,其可能为前列腺癌的诊断提供有价值的指标。
Objective To investigate the relationship between serum copper and zinc levels and prostate cancer, and compare the serum level of prostate specific antigen (PSA) with that of serum prostate specific antigen (PSA) to explore its value in the diagnosis of prostate cancer. Methods The levels of serum copper and zinc in 76 patients with prostate cancer, 125 patients with benign prostatic hyperplasia and 191 healthy men were measured by atomic absorption spectrophotometry. Results Serum zinc in prostate cancer group was significantly lower than that in healthy control group, serum copper and copper / zinc ratio was significantly higher than the healthy control group (P <0.05). There were no significant differences in serum copper and copper / zinc ratio between prostate cancer group and benign prostatic hyperplasia group. Serum zinc in prostate cancer group was lower than benign prostatic hyperplasia group (P <0.05). There was no significant difference between benign prostatic hyperplasia group and healthy control group. The ratio of serum copper and copper / zinc in benign prostatic hyperplasia group was higher than that in healthy control group (P <0.05). PSA in 4.0-10.0 ng / ml gray area of the prostate cancer group, the serum zinc ROC-AUC (receiver operator characteristic curve-area under curve) 66%, higher than the ROC-AUC PSA. Conclusions The serum copper, copper / zinc ratio and serum zinc may be the risk factors of prostate cancer. The diagnostic efficiency of serum zinc in PSA (4.0 ~ 10.0) ng / ml gray area is higher than that of PSA, which may be prostate The diagnosis of cancer provides valuable indicators.