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目的:加强对侵袭性NK细胞白血病(ANKL)的认识。方法:报告新近诊断的1例ANKL患者并行文献复习。结果:ANKL高发于亚洲人群,其发病与EB病毒感染高度相关;白血病细胞的免疫表型特征为CD2+,CD3-,cCD3-,CD16+,CD56+,TCR重排阴性:临床病程进展快速,预后差;主要应与结外NK/T淋巴瘤和惰性NK细胞淋巴细胞增生性疾患相鉴别。结论:ANKL是一种少见的白血病,遇有疑似病例应及时做免疫学表型、基因重排和病理组织学检测,以明确诊断。
OBJECTIVE: To enhance understanding of aggressive NK cell leukemia (ANKL). METHODS: A review of a concurrent literature review of one newly diagnosed ANKL patient was reported. RESULTS: The prevalence of ANKL in Asian population was highly correlated with Epstein-Barr virus (EBV) infection. The immunophenotypic characteristics of leukemia cells were negative for CD2 +, CD3-, cCD3-, CD16 +, and CD56 + rearrangements. The clinical course progressed rapidly and the prognosis was poor. Mainly with the extranodal NK / T lymphoma and inert NK cell lymphoproliferative disorders phase identification. Conclusion: ANKL is a rare leukemia. In case of suspected cases, immunological phenotype, gene rearrangement and pathological examination should be done in time to confirm the diagnosis.