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目的:探讨补肾胶囊对雄性去势大鼠性功能的影响。方法:采用睾丸摘除术造去势大鼠模型。将动物分为5组,分别灌服大、中、小剂量的补肾胶囊混悬液、男宝胶囊混悬液和同体积生理盐水,另设一正常对照组,实验结束时测定大鼠阴茎勃起潜伏期、扑捉潜伏期和扑捉次数;大鼠阴茎、包皮腺、精囊腺、前列腺、提肛肌称重,相应组织的组织切片和光镜观察其组织形态的变化;用放免法测定大鼠血清睾酮、皮质醇含量。结果:大、中、小剂量补肾胶囊组均可显著缩短去势大鼠阴茎勃起潜伏期;大、中剂量补肾胶囊组可显著缩短大鼠扑捉潜伏期,大、中剂量补肾胶囊组可显著增加扑捉次数;大、中、剂量补肾胶囊组可明显提高血清皮质醇水平,大、中剂量补肾胶囊组可明显增加提肛肌质量。结论:补肾胶囊组有促进前列腺和精囊腺分泌作用,有促进阴茎海绵体增大及促进提肛肌发育作用。补肾胶囊具有显著的补肾壮阳作用。
Objective: To investigate the effect of Bushen capsule on sexual function in male ovariectomized rats. Methods: Ovariectomized rat model was made by testicular enucleation. Animals were divided into 5 groups and were respectively fed with large, medium and small doses of Bushen capsule suspension, Menbao capsule suspension and the same volume of normal saline, and another normal control group. The rat’s penile erection was measured at the end of the experiment. Latent period, catching incubation period and number of captures; rat penis, prepuce gland, seminal vesicle, prostate, levator ani muscles were weighed, tissue histological sections of corresponding tissues and light microscopy were used to observe changes in histomorphology; rat serum testosterone was measured by radioimmunoassay. Cortisol content. Results: Large, medium, and small doses of Bushen capsule group can significantly shorten the erectile latency of castration rats; large and medium doses of Bushen Capsule group can significantly shorten the incubation period of rats, and large and medium doses of Bushen Capsule group can significantly increase the rate of Number of catches; large, medium, and dose Bushen Capsule group can significantly increase serum cortisol levels, large and medium dose Bushen Capsule group can significantly increase the levator ani muscle mass. Conclusion: Bushen Capsule can promote the secretion of prostate gland and seminal vesicle, promote the enlargement of cavernous body and promote the development of levator ani muscle. Bushen capsule has a significant effect of kidney yang.