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目的探讨地特胰岛素(Det)对比中性鱼精蛋白锌胰岛素(NPH)联合口服降糖药(OADs)治疗T2DM的疗效和安全性。方法选择60例T2DM患者分别应用Det和NPH联合OADs治疗,比较两组治疗前后FPG、2hPG、低血糖事件发生、BMI及HbA1c变化。结果两组患者治疗12周后FPG、2hPG、HbA1c均较治疗前下降(P<0.05),但Det组下降更显著(P<0.05),Det组对BMI控制优于NPH组(P<0.05),低血糖发生率低。结论与NPH相比,Det联合OADs治疗T2DM疗效更好,低血糖发生率低,对体重影响小。
Objective To investigate the efficacy and safety of Detmin versus Neutral Protamine (NPH) and oral hypoglycemic agents (OADs) in the treatment of T2DM. Methods Sixty patients with T2DM were treated with Det and NPH combined with OADs. The changes of FPG, 2hPG, the incidence of hypoglycaemia, BMI and HbA1c were compared between the two groups before and after treatment. Results The levels of FPG, 2hPG and HbA1c in both groups were significantly decreased after treatment for 12 weeks (P <0.05), but the levels in Det group were significantly lower than those in NP group (P <0.05) , Low incidence of hypoglycemia. Conclusions Compared with NPH, Det combined with OADs is more effective in treating T2DM with low incidence of hypoglycemia and little effect on body weight.