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作者报道用随机法比较口服氟嗪酸(400mg,一天2次)和非肠道药物头孢唑啉(cefazolin)每8小时静注1.0 g或头孢他啶(ceftazidime)每12小时静注2.0 g,治疗经活检确诊的未经修复的(nonprosthesis)骨髓炎的疗效。 19例患者接受氟嗪酸治疗,平均治疗时间为8周。14例接受非肠道抗生素治疗,平均治疗时间为4周。受试者对于这两种疗法都具有良好的耐受性。感染菌类有金黄色葡萄球菌(40%)、肠球菌spp.(3%)、绿脓杆菌(15%)以及其它革兰氏阴性菌(42%)。治疗
The authors reported a randomized trial comparing oral gavan acid (400 mg twice daily) and the parenteral cefazolin intravenously every 1.0 g or ceftazidime every 8 hours to 2.0 g intravenously every 12 hours. Biopsy confirmed nonprosthetic osteomyelitis. Nineteen patients received flufenamic acid, with an average treatment time of 8 weeks. Fourteen patients received parenteral antibiotics, with an average treatment time of 4 weeks. Subjects are well tolerated for both therapies. Staphylococcus aureus (40%), Enterococcus spp. (3%), Pseudomonas aeruginosa (15%), and other Gram-negative bacteria (42%) were infected. treatment