论文部分内容阅读
用本所传代已二十余年、对药物敏感的伯氏鼠疟原虫作种源,每转种一代给小白鼠口服单次量咯萘啶。第1代剂量为8 mg/kg,其后剂量每代增加2 mg/kg。转种至第23代,剂量达2,400mg/kg时,虽部分小鼠死亡,存活小鼠的原虫血症仍不转阴,此时原虫的抗药性为亲代原虫的300倍以上。抗咯萘啶鼠疟原虫(RPB_2)对氯喹、喹哌、吡咯喹、M-6407、阿的平与青蒿素等有一定程度的交叉抗药性。用对亲代原虫有效量的3～10倍治疗RPB_2原虫时,不能使原虫血症转阴。如不再用药,连续转种5代,RPB_2可恢复对咯萘啶的敏感性。
With more than 20 years passed from generation to generation, the drug-sensitive P. murine parasite was used as the germplasm, and single-dose pyronaridine was given orally to the mice after each generation. The first dose of 8 mg / kg, followed by an increase of 2 mg / kg dose. Transplanted to the 23rd generation, a dose of 2,400mg / kg, although some mice died, protozoospermia in surviving mice is still not negative, then the protozoa resistance of protozoan protozoa more than 300 times. Resistant to naphthyridine diphtheria Plasmodium (RPB_2) to chloroquine, Quip, pyrroloquine, M-6407, Aripiprazole and artemisinin have a certain degree of cross-resistance. With the progenitor effective amount of 3 to 10 times the treatment of RPB_2 protozoa, can not make parasitemia negative. If no medication, continuous transformation of 5 generations, RPB_2 can restore the sensitivity of pyronaridine.