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目的:观察对比清金定喘汤联合机械通气与单纯机械通气治疗慢性阻塞性肺部疾病合并呼吸衰竭患者临床疗效。方法:选取102例慢性阻塞性肺部疾病合并呼吸衰竭患者随机分为观察组和对照组,给予不同的治疗方法,比较两组患者临床疗效,治疗前后动脉血气变化、痰液N%、PaO2/FiO2及Cdyn变化、死亡率、并发症发生率、机械通气时间、住院时间。结果:治疗前两组患者动脉血气、痰液N%、PaO2/FiO2及Cdyn差异无统计学意义(P>0.05),两组患者治疗后各观察指标较治疗前均有显著改善,观察组患者治疗后各观察指标较对照组改善更显著,观察组临床疗效有效率显著高于对照组,死亡率、并发症发生率、机械通气时间及住院时间均显著低于对照组,差异均有统计学意义(P<0.05)。结论:清金定喘汤联合机械通气治疗慢性阻塞性肺部疾病合并呼吸衰竭,能够有效地控制肺部炎症,改善患者呼吸,提高临床疗效,降低死亡率、并发症,缩短机械通气时间、住院时间,值得进一步在临床推广应用。
Objective: To observe the clinical efficacy of Qingjin Dingchuang combined with mechanical ventilation and simple mechanical ventilation in the treatment of patients with chronic obstructive pulmonary disease and respiratory failure. Methods: A total of 102 patients with chronic obstructive pulmonary disease and respiratory failure were randomly divided into observation group and control group. Different treatment methods were given to compare the clinical curative effect, arterial blood gas changes before and after treatment, sputum N%, PaO2 / FiO2 and Cdyn changes, mortality, complication rate, duration of mechanical ventilation and length of stay. Results: There was no significant difference in arterial blood gas, sputum N%, PaO2 / FiO2 and Cdyn between the two groups before treatment (P> 0.05). After treatment, the observation indexes in both groups were significantly improved after treatment. In the observation group After treatment, each observation index improved more significantly than the control group, the clinical efficacy of the observation group was significantly higher than the control group, the mortality, the incidence of complications, the duration of mechanical ventilation and hospitalization were significantly lower than the control group, the difference was statistically Significance (P <0.05). Conclusion: Qingjin Dingchuang combined with mechanical ventilation for chronic obstructive pulmonary disease combined with respiratory failure can effectively control lung inflammation, improve patient respiration, improve clinical efficacy, reduce mortality, complications, shorten the duration of mechanical ventilation, hospitalization Time, it is worth further clinical application.