据报道,以聚乙二醇(PEG)为基质时,阿司匹林栓的释放很慢。为此,作者设计了四种栓剂处方,观察不同浓度聚乙烯吡咯烷酮对阿司匹林释放的影响。处方中添加聚乙烯吡咯烷酮的量为0.5％、1％及5％,以25和50转/分两种搅拌速度进行溶出试验。并用分光光度法在265nm的波长处进行阿司匹林的定量。结果证明,聚乙烯吡咯烷酮能加速阿司匹林的溶出,减少溶出一半所需的时间(溶出 Aspirin is reported to release slowly with polyethylene glycol (PEG) as a substrate. To this end, the authors designed four suppository prescriptions to observe the effects of different concentrations of polyvinylpyrrolidone on aspirin release. The amount of polyvinylpyrrolidone added in the formulation was 0.5%, 1%, and 5%, and the dissolution test was conducted at 25 and 50 rpm at two stirring rates. Aspirin was quantified spectrophotometrically at a wavelength of 265 nm. The results show that polyvinylpyrrolidone can accelerate the dissolution of aspirin, reducing the time required to dissolve in half (dissolution