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目的 观察脑出血 (CH)、脑梗死 (CI)、蛛网膜下腔出血 (SAH)患者神经肽 Y(NPY)水平动态变化及其临床意义。方法 选择脑血管病 (CVD)患者 138例 ,其中 CH组 46例 ,CI组 6 2例 ,SAH组 30例。用放免法检测血浆 NPY浓度。结果 CI组、CH组、SAH组 NPY水平显著高于对照组 ,于发病后 2 4h内均显著升高 ,1～3d或 4～ 7d达高峰 ,8～ 15 d开始下降 ,15 d后仍在较高水平 ;重型与大灶组显著高于中、轻型与小灶组 ;发病积分≥6分组显著高于 <6分组 ,伴高血压组显著高于不伴高血压 ;伴消化道出血组显著高于不伴消化道出血组。结论 NPY参与了 CVD及其伴发病的病理生理过程
Objective To observe the dynamic changes of neuropeptide Y (NPY) in patients with cerebral hemorrhage (CH), cerebral infarction (CI) and subarachnoid hemorrhage (SAH) and its clinical significance. Methods Thirty-eight patients with cerebrovascular disease (CVD) were selected, including 46 CH patients, 62 patients in CI group and 30 patients in SAH group. The radioimmunoassay was used to detect plasma NPY concentration. Results The levels of NPY in CI group, CH group and SAH group were significantly higher than those in control group at 24 h after onset, reaching the peak at 1-3 d or 4-7 d, then decreased at 8-15 d and remained at 15 d Higher and higher; heavy and large group were significantly higher than those in medium, light and small group; incidence score ≥6 group was significantly higher than <6 group, with hypertension group was significantly higher than without hypertension; with gastrointestinal bleeding group was significantly higher than Not associated with gastrointestinal bleeding group. Conclusion NPY is involved in the pathophysiological process of CVD and its associated diseases