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目的血清β2-微球蛋白、尿微量白蛋白的测定在早期糖尿病肾病诊断中的意义。方法采用散射比浊法,对常规检测尿蛋白阴性的糖尿病患者进行血清β2-微球蛋白、尿白蛋白的含量检测。结果糖尿病尿蛋白阴性患者的血清β2-微球蛋白及尿白蛋白的含量均显著高于正常对照组。结论联检血β2-微球蛋白、尿白蛋白是预测糖尿病肾损害的简便可行的方法,对糖尿病肾病的早期诊断具有重要的临床价值。
Objective To investigate the significance of serum β2-microglobulin and urinary microalbumin in the diagnosis of early diabetic nephropathy. Methods The turbidimetric method was used to detect serum β2-microglobulin and urinary albumin in patients with routine urine protein-negative diabetes. Results The serum levels of β2-microglobulin and urinary albumin in diabetic patients with negative urinary protein were significantly higher than those in normal controls. Conclusions The combination of serum β2-microglobulin and urinary albumin is a simple and feasible method to predict diabetic nephropathy. It has important clinical value in the early diagnosis of diabetic nephropathy.