疫苗研制过程中通常需要加入一定量的庆大霉素、卡拉霉素等抗生素用作抑制污染菌生长。如果带入到成品疫苗中抗生素残留量过高则会导致人的机体产生异常反应,如皮肤潮红、发痒、心悸、皮疹、呼吸困难,严重者可出现休克或死亡,因此应严格控制疫苗中抗生素的残留。在研制过程中即使通过换洗、纯化以及最终超滤等工艺,也很难将抗生素 Vaccine development process usually need to add a certain amount of gentamicin, kamycin and other antibiotics used to inhibit the growth of contaminated bacteria. If the antibiotic residues brought into the finished vaccine are too high, it will cause abnormal reaction in human body, such as flushing, itching, palpitation, rash and breathing difficulties. In severe cases, shock or death may occur. Therefore, the vaccine should be strictly controlled Residues of antibiotics. Even in the development process through the exchange, purification and the final ultrafiltration and other processes, it is difficult to antibiotics