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目的：探讨炎症因子与十二指肠溃疡的寒热辨证关系。方法：对４８例十二指肠溃疡患者进行中医寒热辨证，胃镜下作胃窦部活检，测定胃粘膜组织白介素８（ＩＬ８）及白介素６（ＩＬ６），并测定肿瘤坏死因子（ＴＮＦ）、丙二醛（ＭＤＡ）、髓过氧化物酶（ＭＰＯ），然后进行对比分析，并与１０例正常胃粘膜活检标本作比较。结果：热证组胃粘膜ＩＬ８、ＴＮＦ、ＭＰＯ及ＭＤＡ较寒证组增多（Ｐ＜００５）；ＩＬ６与寒热辨证无明显关系。结论：炎症因子ＩＬ８、ＴＮＦ、ＭＰＯ及ＭＤＡ与中医寒热辨证有一定的相关性，可能是中医寒热证型形成的物质基础之一。
Objective: To investigate the relationship between inflammatory factors and duodenal ulcer. Methods: Forty-eight patients with duodenal ulcer were subjected to cold and heat syndrome. Gastroscopy under gastroscopy was performed. Gastric mucosa interleukin-8 (IL-8) and interleukin-6 (IL-6) were measured and tumor necrosis factor TNF, MDA and MPO, and then compared with 10 normal gastric biopsy specimens. Results: Heat syndrome group gastric mucosa IL 8, TNF, MPO and MDA increased compared with the cold syndrome group (P <0 05); IL 6 and cold and heat syndrome no significant relationship. Conclusion: IL 8 inflammatory cytokines, TNF, MPO and MDA have some correlation with traditional Chinese medicine cold and heat syndrome, which may be one of the material basis for the formation of TCM syndromes.