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目的:对无症状性脑梗死患者的高敏C-反应蛋白、同型半胱氨酸、纤维蛋白原及血脂不同成分进行分析,探讨上述指标与无症状性脑梗死的关系。方法:高敏C-反应蛋白水平用免疫散射比浊法检测,同型半胱氨酸浓度用酶联免疫吸附法测定,纤维蛋白原用Thrombotimer4自动血凝仪测定,用Olimpus-AU5400全自动生化分析仪进行血脂相关成分的分析,共检测无症状性脑梗死患者216例,对照组210例。结果:无症状性脑梗死组高敏C-反应蛋白、同型半胱氨酸、纤维蛋白原和脂蛋白(α)的水平均较对照组明显升高(均P<0.01),而载脂蛋白A1水平则显著低于对照组(P<0.01);三酰甘油、总胆固醇、高密度脂蛋白、低密度脂蛋白和载脂蛋白B2组间比较差异无统计学意义(均P>0.05)。结论:高敏C-反应蛋白、同型半胱氨酸、纤维蛋白原和脂蛋白(α)升高及载脂蛋白A1降低均是无症状性脑梗死患者的高危危险因素。
OBJECTIVE: To analyze the different components of high-sensitivity C-reactive protein, homocysteine, fibrinogen and blood lipids in asymptomatic patients with cerebral infarction to explore the relationship between these indexes and asymptomatic cerebral infarction. Methods: High-sensitivity C-reactive protein level was detected by immune nephelometry. Homocysteine concentration was measured by enzyme-linked immunosorbent assay. Fibrinogen was measured by Thrombotimer 4 auto-coagulation analyzer. Olimpus-AU5400 automatic biochemical analyzer Blood lipids related components were analyzed, a total of 216 patients with asymptomatic cerebral infarction, control group of 210 patients. Results: The levels of high sensitivity C-reactive protein, homocysteine, fibrinogen and lipoprotein (α) in asymptomatic cerebral infarction group were significantly higher than those in control group (all P <0.01), while apolipoprotein A1 The levels of triglyceride, total cholesterol, high density lipoprotein, low density lipoprotein and apolipoprotein B2 had no significant difference (all P> 0.05). CONCLUSIONS: High-sensitivity C-reactive protein, homocysteine, fibrinogen, and elevated lipoprotein (a) and decreased apolipoprotein A1 are risk factors for high-risk patients with asymptomatic cerebral infarction.