肺癌是世界范围内致死率最高的癌症,而肺癌的预后与诊断时的临床分期密切相关,因此“早期发现、早期诊断、早期治疗”是降低肺癌病死率的重要措施。肺癌高危人群痰脱落细胞中有异质性核核糖核蛋白A2/B1与端粒酶逆转录酶活性的高表达,通过联合检测是否可发现处于早期和可治疗阶段的肿瘤,从而潜在降低肺癌的病死率,因此痰液异质性核核糖核蛋白A2/B1和端粒酶逆转录酶的联合检测是对肺癌早期诊断的一个有益探索。 Lung cancer is the most lethal cancer in the world. The prognosis of lung cancer is closely related to the clinical stage of the diagnosis. Therefore, “early detection, early diagnosis and early treatment” are important measures to reduce the mortality of lung cancer. High-risk population of lung cancer sputum exfoliated cells with heterogeneous nuclear ribonucleoprotein A2 / B1 and telomerase reverse transcriptase activity of high expression, by the joint detection of early and treatable stage of the tumor can be found, which potentially reduce lung cancer Therefore, the combined detection of sputum heterogeneous nuclear ribonucleoprotein A2 / B1 and telomerase reverse transcriptase is a useful exploration for the early diagnosis of lung cancer.