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目的 探讨CT引导下利用锚状电极射频消融治疗兔肺VX2肿瘤的病理改变、CT表现及治疗效果。方法 采用VX2肿瘤组织块悬液肺内注入法在 36只新西兰白兔体内建立兔VX2肿瘤肺内移植模型。实验组 2 8只新西兰白兔给予射频治疗 ,其中 14只于治疗后不同时间处死 ,观察其病理改变 ,并与同期CT表现相比较 ;其余 14只待其自然死亡 ,计算存活时间。对照组 8只新西兰白兔 ,予假性治疗 ,待其自然死亡 ,计算存活时间。结果 肿瘤经射频治疗后发生凝固性坏死及细胞凋亡 ,消融灶周围肺组织发生严重炎症反应 ;CT表现为絮状阴影 ,并随炎症的消散而消失 ,但肿瘤阴影不再增大。实验组 2 1只兔肺内毁损区肿瘤细胞全部灭活 ,7只毁损区有残存活肿瘤细胞。治疗组动物的存活时间为 ( 38± 3.4)天 ,对照组存活时间为 ( 2 6± 2 .8)天 (P <0 .0 5 )。结论 射频消融技术可望成为治疗肺内肿瘤的新方法。
Objective To investigate the pathological changes, CT findings and therapeutic effects of CT-guided radiofrequency catheter ablation on rabbit VX2 tumors in rabbits. Methods Rabbit VX2 tumor lung transplantation model was established in 36 New Zealand white rabbits by intra-lung infusion of VX2 tumor tissue suspension. Twenty-eight New Zealand white rabbits in the experimental group were given radiofrequency ablation. Fourteen of them were sacrificed at different time points after treatment. The pathological changes were observed and compared with the CT findings at the same period. The remaining 14 were sacrificed and the survival time was calculated. Eight New Zealand white rabbits in the control group were given pseudo-treatment and their natural death was calculated. The survival time was calculated. Results The tumor had coagulation necrosis and apoptosis after radiofrequency ablation. The lung tissue around the ablation zone had a serious inflammatory reaction. The CT showed flocculent shadows and disappeared with the disappearance of inflammation, but the tumor shadow no longer increased. Twenty-one rabbits in the experimental group were completely inactivated by tumor cells in the lung, and survived in 7 of the rabbits. The survival time of the treated animals was (38 ± 3.4) days and that of the control group was (26 ± 2. 8) days (P <0.05). Conclusion RFA is expected to become a new method for the treatment of lung tumors.