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灭吐灵亦名胃复安(metoclopramide),系临床用于治疗恶心、呕吐的常用药物。近来我们遇到3例应用灭吐灵引起锥体外系症状,现报告如下。病例报告例1:女,13岁。平素健康,于1980年4月10日因“急性尿路感染”伴恶心、呕吐在某医院就诊。口服灭吐灵8毫克,每日3次,磺胺甲基异噁唑(SMZ)1.0克每日2次,甲氧苄氨嘧啶(磺胺增效剂TMP)0.1克每日2次。服药至第3天突然出现双下肢不自主运动,行走困难,头向后仰,双眼上翻,乃于4月12日来院急诊。距首次服药时间为72小时。
Metoclopramide, also known as metoclopramide, is clinically used to treat nausea and vomiting. Recently, we encountered three cases of methotrexate extrapyramidal symptoms, are as follows. Case Report Example 1: Female, 13 years old. Usually healthy, in April 10, 1980 due to “acute urinary tract infection” with nausea, vomiting in a hospital. 8 mg of oral metoclopramide, 3 times a day, sulfamethoxazole (SMZ) 1.0 g twice daily, trimethoprim (sulfonamide synergist TMP) 0.1 g twice daily. Take medication to the first three days of sudden emergence of involuntary movement of both lower extremities, walking difficulties, head back, eyes closed, but in April 12 to hospital emergency. The first medication from the time of 72 hours.