论文部分内容阅读
目的 :比较西沙必利、雷尼替丁和硫糖铝对功能性消化不良 (FD)的临床疗效。方法 :将 72例门诊FD病人随机分为西沙必利组 (32例 )、雷尼替丁组 (2 2例 )和硫糖铝组 (18例 ) ;分别口服西沙必利 5mg/次 ,3次 /d ,雷尼替丁 15 0mg/次 ,2次 /d和硫糖铝 1.0g/次 ,3次 /d ,疗程均为 4周。治疗后比较三组主要症状变化及总体疗效。结果 :西沙必利对早饱、腹胀的改善非常显著地优于雷尼替丁和硫糖铝 (均为P <0 .0 0 1) ;上腹痛的改善西沙必利与雷尼替丁、硫糖铝相比无差异 (P >0 .0 5 )。其它症状因例数少未进行统计学处理。三组总体疗效以西沙必利最高 ,总有效率达 90 .6 % ,显著优于雷尼替丁和硫糖铝 (分别为P <0 .0 0 5和P <0 .0 0 1) ;而雷尼替丁与硫糖铝总有效率分别为 5 0 .0 %和 38.9% ,差异无显著性 (P >0 .0 5 )。三组不良反应均轻微 ,发生率相当。结论 :对FD的治疗以西沙必利最为有效 ,其疗效显著优于雷尼替丁和硫糖铝 ;而雷尼替丁和硫糖铝疗效基本相当 ,均很有限。提示对FD治疗应以西沙必利为一线首选药物。
Objective: To compare the clinical efficacy of cisapride, ranitidine and sucralfate in patients with functional dyspepsia (FD). Methods: 72 outpatients with FD were randomly divided into cisapride group (n = 32), ranitidine group (n = 22) and sucralfate group (n = 18) Ranitidine 15 0mg / time, 2 times / d and sucralfate 1.0g / time, 3 times / d, the course of treatment were 4 weeks. After treatment, the three groups were compared the main symptoms and the overall effect. RESULTS: Cisapride improved significantly on early satiety and bloating compared with ranitidine and sucralfate (both P <0.01 1); improvement of upper abdominal pain Cisapride and ranitidine, There was no difference in sucralfate (P> 0.05). Other symptoms due to fewer cases of statistical treatment. The overall efficacy of cisapride was highest in all three groups, with a total effective rate of 90.6%, significantly better than ranitidine and sucralfate (P <0.05 and P <0.01, respectively). The total effective rates of ranitidine and sucralfate were 50.0% and 38.9%, respectively, with no significant difference (P> 0.05). Three adverse reactions were mild, the incidence was quite. CONCLUSIONS: Cisapride is the most effective treatment for FD and its efficacy is significantly better than that of ranitidine and sucralfate. The effects of ranitidine and sucralfate are quite similar, both of which are very limited. Prompt treatment of FD should cisapride as the preferred drug.