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目的观察复方樟柳碱联合物理疗法用于弱视治疗的疗效,并对其作用机制进行初步探讨。方法300例门诊弱视患者(3～14岁)分为2组,即治疗组和对照组各150例。治疗组在物理疗法基础上联合复方樟柳碱患眼颞浅动脉旁皮下注射,对照组只用物理疗法。随访3个月,观察视力并比较视网膜中央动脉收缩期峰值流速(retinal artery peak systolic velocity,PSV)及舒张期阻力指数(diastolic resistance index,RI)变化。结果治疗组总有效率68.0%,对照组总有效率36.7%,治疗组与对照组相比,在不同年龄、不同程度弱视组间的有效率差异均有统计学意义(P<0.05)。注射樟柳碱后PSV增高(P<0.05),RI无变化(P>0.05)。结论复方樟柳碱联合物理疗法治疗不同年龄、不同程度弱视患儿均安全有效。其机制可能与视网膜血液供应增加、组织灌注改善有关。
Objective To observe the curative effect of compound anisodine combined with physical therapy on amblyopia and its mechanism of action. Methods 300 outpatients with amblyopia (3 to 14 years old) were divided into two groups, namely, the treatment group and the control group of 150 cases. The treatment group combined with compound anisodine on the basis of physical therapy subcutaneous injection of the superficial temporal artery, the control group only physical therapy. The patients were followed up for 3 months. Visual acuity was observed and the changes of retinal artery peak systolic velocity (PSV) and diastolic resistance index (RI) were compared. Results The total effective rate was 68.0% in the treatment group and 36.7% in the control group. There was significant difference in the effective rates between the treatment group and the control group in different ages and degrees of amblyopia (P <0.05). After injection of anisodine PSV increased (P <0.05), RI no change (P> 0.05). Conclusion Compound anisodine combined with physical therapy of different ages, different degrees of amblyopia in children are safe and effective. The mechanism may be related to increased retinal blood supply and tissue perfusion.