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目的:探讨丹参注射液辅佐神经节苷酯治疗新生儿缺氧缺血性脑病(HIE)的临床应用价值。方法:将70例新生儿HIE患儿随机分为观察组和对照组,对照组采用对症支持治疗,观察组应用神经节苷酯20 mg及丹参注射液4 mL,均静脉点滴,1次/d,连续2周。比较两组患儿治疗效果,新生儿神经行为(NBNA)评分变化及患儿惊厥、意识障碍、原始反射异常及肌张力异常改善时间。结果:观察组患儿有效率为94.29%,显著高于对照组患儿的77.14%,(P<0.05)。治疗后1周及2周,两组患儿NBNA评分均显著改善,与治疗前相比均差异显著(P<0.05)。观察组治疗后NBNA评分改善更显著(P<0.05);观察组患儿惊厥、意识障碍、原始反射异常及肌张力异常改善的时间均显著短于对照组(P<0.05)。结论:丹参注射液辅佐神经节苷酯治疗新生儿HIE治疗效果好,具有良好的应用价值。
Objective: To investigate the clinical value of salvia miltiorrhiza injection in adjuvant ganglioside treatment of neonatal hypoxic-ischemic encephalopathy (HIE). Methods: Seventy neonates with HIE were randomly divided into observation group and control group. The control group was treated with symptomatic supportive therapy. The observation group received 20 mg of ganglioside and 4 mL of Danshen injection, For 2 consecutive weeks. The therapeutic effects, neonatal neurobehavioral (NBNA) scores and the improvement of convulsions, disturbance of consciousness, abnormal reflexes and dystonia were compared between the two groups. Results: The effective rate in observation group was 94.29%, which was significantly higher than that in control group (77.14%, P <0.05). The NBNA scores of both groups were significantly improved at 1 week and 2 weeks after treatment, which were significantly different from those before treatment (P <0.05). NBNA scores improved more significantly in observation group after treatment (P <0.05). The time of improvement of convulsion, disturbance of consciousness, abnormal reflex of original reflex and muscle tone in observation group were significantly shorter than those in control group (P <0.05). Conclusion: Danshen injection adjuvant ganglioside treatment of neonatal HIE treatment effect is good, with good value.