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选取2型糖尿病(T2DM)患者282例检测空腹C-肽、甘油三酯、胆固醇、LDL-C、HbA1c、尿白蛋白/肌酐,并查眼底及测定颈动脉内膜中层厚度(IMT)。根据患者血清C肽水平将其分为正常C肽组与低C肽组。结果正常C肽组HbA1c、甘油三酯、胆固醇、LDL-C显著低于低C肽组;正常C肽组糖尿病视网膜病变(diabetic retinopathy,DR)、糖尿病肾病(diabetic nephropathy,DN)的发生率显著低于低C肽组;正常C肽组颈动脉内膜中层厚度均值显著高于低C肽组;结论血清C肽与糖尿病视网膜病变、糖尿病肾病呈负相关,与颈动脉内膜厚度呈正相关。血清C肽可能是DN、DR的保护因素,其下降可能导致了T2DM微血管病变的发生发展,2型糖尿病中升高的C肽可能反映动脉粥样硬化的发生。
Fasting C-peptide, triglyceride, cholesterol, LDL-C, HbA1c, urinary albumin / creatinine were detected in 282 patients with type 2 diabetes mellitus (T2DM) and fundus examination and carotid intima-media thickness (IMT) were measured. Patients were divided into normal C-peptide group and low-C-peptide group according to serum C-peptide level. Results The levels of HbA1c, triglyceride, cholesterol and LDL-C in normal C peptide group were significantly lower than those in low C peptide group. The incidence of diabetic retinopathy (DR) and diabetic nephropathy (DN) in normal C peptide group was significantly Lower than the low C peptide group; mean carotid intima-media thickness in normal C peptide group was significantly higher than low C peptide group; Conclusion Serum C-peptide was negatively correlated with diabetic retinopathy, diabetic nephropathy and carotid intima-media thickness. Serum C-peptide may be the protective factor of DN and DR, and its decline may lead to the occurrence and development of T2DM microangiopathy. The elevated C-peptide in type 2 diabetes may reflect the occurrence of atherosclerosis.