炎症性结肠疾病和大肠癌是影响人类健康的主要消化系统疾病之一,其发病机理至今尚未完全明了。大量的流行病学调查发现溃疡性结肠炎和Crohn病的发病具有家族倾向,在大多数患病家系中所有患者均患同种类型疾病,而部分家系中有部分患者表现为溃疡性结肠炎,另外一部分患者则患有Crohn病。这提示炎症性肠病(IBD)均有一种共同的遗传基础,而具体发展成为溃疡性结肠炎还是Crohn病则由外部环境决定。Hodgon认为具炎症性肠病易患素质者,若为吸烟者,多发展成为 Inflammatory colon disease and colorectal cancer are one of the major diseases of the digestive system that affect human health, and its pathogenesis has not yet been fully understood. A large number of epidemiological investigations have found that the incidence of ulcerative colitis and Crohn’s disease has a familial tendency. In most affected families, all patients suffer from the same type of disease, and some families have ulcerative colitis. Another group of patients suffer from Crohn’s disease. This suggests that inflammatory bowel disease (IBD) has a common genetic basis, but the specific development of ulcerative colitis or Crohn’s disease is determined by the external environment. Hodgon believes that people with inflammatory bowel disease susceptibility, if they are smokers, develop more and more