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目的研究右美托咪定对老年食管癌根治术患者的认知功能及血气指标的影响。方法 120例食管癌根治术患者按照随机数表法随机均分为研究组和对照组,均采用麻醉诱导及维持方式对患者实施麻醉,研究组在此基础上在麻醉诱导期给予右美托咪定,对照组则在同期给予生理盐水。记录两组患者手术前后认知功能、血气指标。结果术后对照组患者的认知功能评分显著降低(P<0.05),研究组明显高于对照组(P<0.05)。研究组1、3、7 d认知功能障碍发生率(17.95%、5.13%、0)明显低于对照组(48.72%、30.77%、12.82%)(P<0.05)。两组血气指标均有明显改善(P<0.05),研究组明显优于对照组(P<0.05)。研究组术后并发症发生率(10.26%)明显低于对照组(30.77%)(χ2=4.6154,P=0.0317)。结论右美托咪定对老年食管癌根治术患者的认知功能及血气指标的影响较小,预后良好。
Objective To study the effect of dexmedetomidine on cognitive function and blood gas index in patients with esophageal cancer undergoing radical operation. Methods A total of 120 esophageal cancer patients undergoing radical surgery were randomly divided into study group and control group according to the random number table. All patients were anesthetized by induction and maintenance of anesthesia. On the basis of this, the study group was given dexmedetomidine Set, the control group was given saline at the same period. The cognitive function and blood gas index were recorded before and after operation in two groups of patients. Results The score of cognitive function in the control group was significantly lower (P <0.05), and the study group was significantly higher than that of the control group (P <0.05). The incidence of cognitive dysfunction (17.95%, 5.13%, 0) on the 1st, 3rd, 7th day in the study group was significantly lower than that in the control group (48.72%, 30.77%, 12.82%) (P <0.05). The blood gas indexes of both groups were significantly improved (P <0.05), and the study group was significantly better than the control group (P <0.05). The incidence of postoperative complications in the study group (10.26%) was significantly lower than that in the control group (30.77%) (χ2 = 4.6154, P = 0.0317). Conclusion Dexmedetomidine has little effect on cognitive function and blood gas index in patients with esophageal cancer undergoing radical operation, and the prognosis is good.