麦角胺用于流产和防治偏头痛,口服后很快被代谢,首过作用显著。测定麦角胺血药浓度的方法很多,但灵敏度均低。作者采用了新发展的三段质谱技术(triple sector mass spectrometric technique),将电极直接插入血浆提取液中作质谱分析。24名健康受试者(男女各半)采用随机交叉,分别给予2mg麦 Ergotamine for abortion and prevention of migraine headaches, soon after oral metabolism, the first pass significant effect. There are many ways to determine the plasma concentration of ergotamine, but the sensitivity is low. The authors used the newly developed triple sector mass spectrometric technique to insert electrodes directly into plasma extracts for mass spectrometry analysis. Twenty-four healthy subjects (half male and female) were randomized to 2 mg of wheat