超广谱β 内酰胺酶 (ＥＳβＬｓ)是由多种革兰氏阴性杆菌产生的新型β 内酰胺酶。它能强力水解氨曲南以及头孢菌素类抗生素 ,从而导致治疗失败。采用肉汤稀释法 ,通过不同的接种量 ,分别测定了美洛培南、头孢吡肟、唑巴克坦、头孢替坦、头孢曲松、头孢噻肟、头孢他定、氨曲南等 Extended spectrum beta-lactamase (ESβLs) is a novel beta-lactamase produced by a variety of Gram-negative bacilli. It can hydrolyze Aztreonam and cephalosporins antibiotics, leading to failure of treatment. The concentration of meropenem, cefepime, azabactam, cefotetan, ceftriaxone, cefotaxime, ceftazidime, aztreonam and so on were determined by broth dilution method through different inoculum sizes