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目的探讨高碘摄入的大鼠甲状腺超微结构的变化及硒对其的干预作用。方法 Wistar大鼠随机分为对照组、高碘组和高碘加硒组,高碘加硒组灌胃给予亚硒酸钠,观察实验结束时各组大鼠电镜下甲状腺的超微结构。结果高碘组大鼠甲状腺滤泡上皮细胞破坏、凋亡,线粒体、高尔基体肿胀,与高碘组相比,高碘加硒组大鼠甲状腺细胞学破坏减轻。结论高碘摄入可造成大鼠甲状腺滤泡破坏、凋亡,提示功能受损,而硒对此有保护作用。
Objective To investigate the ultrastructural changes of thyroid in rats with high iodine intake and the effect of selenium on it. Methods Wistar rats were randomly divided into control group, high iodine group and high iodine plus selenium group, high iodine and selenium group were intragastrically administered with sodium selenite. The ultrastructure of thyroid gland under electron microscope was observed at the end of the experiment. Results Thyroidal follicular epithelial cells were destroyed, apoptotic, mitochondria and Golgi were swollen in high iodine group. Compared with high iodine group, thyroid cytology of rats in high iodine and selenium group were relieved. Conclusion High iodine intake can cause thyroid follicular destruction and apoptosis in rats, suggesting impaired function, while selenium has a protective effect.