在确定了药物的用量之后,合理地掌握其应用时间间隔,对充分发挥药效,避免或减低毒副反应具有重要意义。由于药物的作用性质和半衰期各不相同,故用药的时间间隔也不一样。一、延缓细菌生长期抗生素的应用时间间隔近年来认为,不少抗生素的疗效主要取决于血药浓度高峰,而与持续血药浓度关系不大。如结核病的首选药物异烟肼,传统用法是每日三次。由于 After determining the amount of drugs, a reasonable grasp of the application of time intervals, to give full play to efficacy, to avoid or reduce toxicity is of great significance. Due to the nature of the drug and the half-life vary, so the medication interval is not the same. First, to delay the growth of antibiotics in the bacterial growth period of time intervals in recent years that the efficacy of many antibiotics depends mainly on the peak concentration of plasma concentration, and has little to do with the continuous plasma concentration. Such as tuberculosis drug of choice isoniazid, the traditional usage is three times a day. due to