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小鼠腹腔巨噬细胞培养基中加入藻酸双酯钠,浓度大于10μg/mL时,培养基内6-酮-前列腺素F_(1α)和血栓烷B_2含量显著增加(P<0.001),并具剂量依赖性特点。藻酸双酯钠刺激前列腺素合成的作用可能是其心血管作用的机制之一。
The concentration of 6-keto-prostaglandin F_ (1α) and thromboxane B_2 in the medium of peritoneal macrophages was significantly increased (P <0.001) at the concentration of more than 10μg / mL A dose-dependent characteristics. Sodium alginate Stimulation of prostaglandin synthesis may be one of the mechanisms of its cardiovascular effects.