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钩吻素子(A)是从草药钩吻(又名断肠草,大茶叶Gelsemium elegans benth)中分离出来的。该化合物是50年前(1931)由前上海药物研究所赵承嘏所长分离出来,并定出了分子式C_(20)H_(22)N_2O,但当时对该化合物的结构式一无所知,60年代初我们在中国科学院上海有机化学研究所开始测定其结构,限于当时的条件,仅利用红外,紫外光谱和一些化学方法测出了它的发色基团(芳香环系统)和功能团。
Koukina (A) is isolated from Herbal Herbs (also known as Herba Gelsemium elegans benth). The compound was isolated 50 years ago (1931) from Zhao Chenglian, former director of Shanghai Institute of Materia Medica, and the molecular formula of C 20 H 22 N 2 O was determined. At that time, In the early 60s, we began to determine its structure at the Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences. Due to its limited conditions, its chromophore (aromatic ring system) and its functional groups were detected only by infrared and ultraviolet spectra and some chemical methods.