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风心病患者HLA-DR4阳性率较高(72%),且有遗传倾向;HLA-DR6阳性率很低,不易患风心病,两者均有重要的临床流行病学意义.患者辅助性T淋巴细胞和杀伤性T淋巴细胞增多,但其后者功能活性降低,提示细胞免疫反应增强.慢性风湿性心瓣膜病即使临床无风湿活动依据,B淋巴细胞数仍然持续增高,表明体内异常的免疫反应并未静止.被乙型A族链球菌M型蛋白质激活的人体T杀伤细胞能攻击人体心肌细胞,这是风心病心脏病变的免疫病理学基础.
The prevalence of HLA-DR4 in patients with rheumatic heart disease is high (72%), and has a genetic predisposition; the positive rate of HLA-DR6 is very low and is not susceptible to rheumatic heart disease, both of which have important clinical epidemiological significance. Cells and killer T lymphocytes increased, but the latter functional activity decreased, suggesting an increase in cellular immune response.Chronic rheumatic heart disease, even if the clinical rheumatoid activity based on the number of B lymphocytes continued to increase, indicating that the body’s abnormal immune response Not Quiescent Human T killer cells activated by type B group A streptococcal M-type protein can attack human cardiomyocytes, which is the immunopathological basis of rheumatic heart disease.