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目的 :观察应用国产干扰素 (赛若金 )治疗慢性乙型肝炎的疗效 ,并进行随访。方法 :84例慢性乙型肝炎患者随机分为两组 ,治疗组42例 ,应用国产干扰素IFNα1b(商品名 :赛若金 )肌肉注射 ,1周3次 ,1次5MU ,对照组42例 ,使用常规保肝药物 ,两组疗程均为6个月。结果 :疗效结束时 ,两组临床症状及体征改善 ,治疗组优于对照组 (P<0 01) ,治疗组肝功能指标ALT恢复率89 6 %优于对照组ALT恢复率51 3 % (P<0 05)。停药后2年随访结果比较 ,治疗组HBsAg阴转率 ,HBVDNA阴转率及HBeAgHBVDNA双阴转率分别为45 9 %、54 2 %和40 5 % ,与对照组比较P<0 01 ,差异有非常显著意义。结论 :IFNα1b(赛若金 )对治疗慢性乙型肝炎的疗效 ,无论是近期还是远期 ,效果都是确切的
Objective: To observe the curative effect of domestic interferon (Cytokinin) on chronic hepatitis B and follow-up. Methods: Eighty-four patients with chronic hepatitis B were randomly divided into two groups. The treatment group received 42 intramuscular injections of interferon IFNα1b (trade name: Sailolin), 3 times a week, 1 time 5 MU, 42 cases in control group, Using conventional hepatoprotective drugs, both groups were treated for 6 months. Results: At the end of the treatment, the clinical symptoms and signs of the two groups were improved, and the treatment group was better than the control group (P <0.01). The recovery rate of ALT in the treatment group was 89 6% better than that in the control group 51 3% (P <0 05). After 2-year follow-up, the HBsAg negative conversion rate, HBVDNA negative conversion rate and HBeAg HBVDNA double negative conversion rate were 45 9%, 54 2% and 40 5% respectively in the treatment group, P <0.01 compared with the control group Have very significant meaning. Conclusions: The efficacy of IFNα1b in treating chronic hepatitis B, both in the near future and in the long term, is accurate