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目的研究60 Coγ射线对平滑肌细胞增殖的影响及机制。方法采用同位素技术 ,测定3 H TdR掺入和丝裂素活化蛋白激酶 (MAPK)活性。结果 1 4、2 8Gy60 Coγ射线明显抑制平滑肌细胞增殖 ,同时MAPK活性明显下降。结论 60 Coγ射线抑制平滑肌细胞增殖可能是通过降低MAPK活性途径实现的。
Objective To investigate the effects of 60 Co γ-ray on the proliferation of smooth muscle cells and its mechanism. Methods The incorporation of 3 H TdR and mitogen-activated protein kinase (MAPK) activity were measured using isotope techniques. Results 1 4,2 8Gy60 Coγ-ray significantly inhibited the proliferation of smooth muscle cells, while MAPK activity was significantly decreased. Conclusions 60 Co γ-ray can inhibit the proliferation of smooth muscle cells by reducing MAPK activity.