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目的探讨HCG日子宫内膜厚度及类型对体外受精-胚胎移植(IVF-ET)临床结局的相关性。方法回顾性分析行体外受精-胚胎移植助孕1218例患者,HCG日经阴道超声进行子宫内膜厚度、子宫内膜类型测量。子宫内膜厚度分为3组:分别是<8mm组(168周期)、8-11mm组(694周期)、>11mm组(356周期);根据内膜回声类型分成A型、B型、C型,比较不同子宫内膜厚度组及子宫内膜类型的临床结局。结果胚胎移植1218例,临床妊娠率为45.32%,活产率为37.27%。三组不同子宫内膜厚度的妊娠率分别为38.10%、44.81%及49.72%,有显著性差异(P<0.05),但活产率无统计学差异(P>0.05)。子宫内膜厚度与临床妊娠率呈正相关性(r=0.852,P=0.03)。ROC曲线下面积为0.54,显示子宫内膜厚度不是预测妊娠的准确指标。三组不同子宫内膜类型的妊娠率(分别为50.43%、44.80%、41.96%)、着床率及活胎分娩率无显著性差异(P>0.05)。结论 1.HCG日子宫内膜厚度与IVF-ET临床妊娠率呈正相关性,但尚不能用HCG日子宫内膜厚度-作为预测妊娠的判断指标。2.HCG日子宫内膜的类型不影响IVF-ET临床结局。
Objective To investigate the correlation between endometrial thickness and type of HCG on clinical outcomes of in vitro fertilization-embryo transfer (IVF-ET). Methods Retrospective analysis of 1,218 cases assisted by IVF-ET was performed. The thickness of endometrium and the type of endometrium were measured by transvaginal HCG. Endometrial thickness was divided into three groups: <8mm group (168 cycles), 8-11mm group (694 cycles),> 11mm group (356 cycles); according to the type of endometrial echoes divided into A, B, C , Compare different endometrial thickness group and endometrial type of clinical outcome. Results 1218 embryo transfer cases, the clinical pregnancy rate was 45.32%, the live birth rate was 37.27%. The pregnancy rates of three groups of different endometrial thickness were 38.10%, 44.81% and 49.72% respectively, with significant difference (P <0.05), but there was no significant difference in live birth rate (P> 0.05). Endometrial thickness and clinical pregnancy rate was positively correlated (r = 0.852, P = 0.03). The area under the ROC curve was 0.54, indicating that endometrial thickness is not an accurate indicator of pregnancy predictions. The pregnancy rates of three groups of different endometrial types (50.43%, 44.80%, 41.96%, respectively), implantation rate and live birth rate showed no significant difference (P> 0.05). Endometrial thickness at HCG day was positively correlated with the clinical pregnancy rate of IVF-ET, but the endometrial thickness at HCG day was not yet available as a predictor of pregnancy prediction. 2.HCG endometrial type does not affect the IVF-ET clinical outcome.