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碳青霉烯类(如亚胺培南和美罗培南)最常用于产ESBL和/或去阻遏AmpC肠杆菌所致严重感染的治疗,但具有碳青霉烯类水解活性的A类酶的出现,使抗感染治疗步入困境。依据系统发生关系,A类碳青霉烯酶分为包括GES、KPC、SME、IMI/NMC-A、SHV-38和SFC-16个不同的群。除KPC、GES和IMI-2的编码基因位于可移动元件外,其他均位于染色体。这类酶水解青霉素类、早期的头孢菌素类、单酰胺类、以及亚胺培南和美罗培南。依据Bush-J-M分类系统,这些酶分为4个不同的表型亚群,即2br,2be,2e和2f。与其他A类β-内酰胺酶一样,A类碳青霉烯酶可被克拉维酸和他唑巴坦抑制。
Carbapenems such as imipenem and meropenem are most commonly used in the treatment of ESBL-producing and / or derepressing severe infections caused by AmpC enterobacteriae, but the presence of class A enzymes with carbapenem-hydrolyzing activity, Anti-infective treatment into trouble. Based on phylogenetic relationships, class A carbapenemases are divided into 16 distinct populations including GES, KPC, SME, IMI / NMC-A, SHV-38 and SFC-16. In addition to KPC, GES and IMI-2 encoding genes are located outside the movable element, the other are located in the chromosome. Such enzymes hydrolyze penicillins, early cephalosporins, monoamides, and imipenem and meropenem. According to the Bush-J-M classification system, these enzymes are divided into four distinct phenotypic subgroups, 2br, 2be, 2e and 2f. Like other class A [beta] -lactamases, class A carbapenemases can be inhibited by clavulanic acid and tazobactam.